In many countries, mating between close relatives is forbidden by law.įor example, mating between first- or second-degree relatives is explicitly prohibited by the Sexual Offences Act (2003) in the UK. It also considers that of children born from the intercourse of half-siblings (second degree). This includes children created when parents and their offspring (first degree) have a child. If this is significantly higher than normal, it can indicate a person's parents are closely related.Įxtreme inbreeding (EI) is often defined as genome-wide homozygosity consistent with mating between first or second degree relatives. Homozygosity is the term given to stretches of the genetic code that are identical, and therefore must have been inherited from both the mother, and the father. According to the guidelines from the American College of Medical Genetics, extreme inbreeding can be suspected if over 10 per cent of the DNA sequence in an individual has runs of homozygosity.
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